The new Euskalmet coastal–maritime warning system

This work presents the main characteristics of the Basque Meteorology Agency (Euskalmet) maritime–coastal risk warning system, with special emphasis on the latest updates, including a clear differentiation on specific warning messages addressing sea conditions for navigation purposes in the first 2 nautical miles, and expected coastal impacts. Some details of the warning bulletin for maritime and coastal risk situations are also presented, together with other communication products and strategies used in coastal and maritime severe episodes at the Basque coast. Today, three different aspects are included in the coastal–maritime risk warning system in Basque Country, related to the main potential severe events that affecting coastal activities. – "Galerna" risk relates to a sudden wind reversal that can severely affect coastal navigation and recreational activities. – "Navigation" risk relates to severe sea state conditions for 0–2 miles, affecting different navigation activities. – "Coastal impact" risk relates to adverse wave characteristics and tidal surges that induce flooding events and different impacts in littoral areas.The authors would like to thank Emergencies and Meteorology Directorate – Security Department alerting for the dangerousness of temporal coincidence – Basque Government for public provision of data and operational of the key factors. service financial support

Dynamics of a model of Toxoplasmosis disease in human and cat populations

AbstractA mathematical model for the transmission of Toxoplasmosis disease in human and cat populations is proposed and analyzed. We explore the dynamics of the Toxoplasmosis disease at the population level using an epidemiological type model. Discussion of the basic concepts of the Toxoplasmosis transmission dynamics on human and cat populations are presented. The cats in this model plays a role of infectious agents and host of the protozoan Toxoplasma Gondii parasite. Qualitative dynamics of the model is determined by the basic reproduction number, R0. If the threshold parameter R0<1, then the solution converges to the disease free equilibrium point. On the other hand if R0>1 the convergence is to the endemic equilibrium point. Numerical simulations of the model illustrates several different dynamics depending on the threshold parameter R0 and show the importance of this parameter

Homogenization of magnetoelastic heterogeneous solid bodies based on micropolar magnetoelasticity

A variational-based homogenization method for magnetoelastic composite materials is established in a small strains framework. The existence of a non-symmetrical stress tensor motivates the elaboration of a homogenized Cosserat type magnetoelastic effective medium at the macroscale. Generic expressions of the effective magnetic and elastic properties are derived, showing the existence of couplings between the elastic and magnetic behaviors at the macrolevel. Applications of the developed homogenization methodology are done for periodic heterogeneous media prone to local bending at the scale of a few unit cells. The validation of the homogenized medium is performed by comparing its predictions versus those of fully resolved computations. The influence of the magnetic field intensity and orientation on the strength of micropolar effects is assessed. The proposed formulation opens new possibilities for the efficient design of multifunctional metamaterials via computational modelling.The authors acknowledge support from MCIN/ AEI /10.13039/501100011033 under Grant number PID2020-117894GA-I00. The authors acknowledge support from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 947723, project: 4D-BIOMAP). DGG acknowledges support from the Talent Attraction grant (CM 2018-2018-T2/IND-9992) from the Comunidad de Madrid

Rendimento académico e desportivo em jovens desportistas do Centro de Tecnificação Desportiva do Cheste

Resumen: Introducción: La relación entre el nivel de condición física y el rendimiento académico ha sido objeto de estudio desde hace décadas habiendo sido corroborada esta asociación en la población general infantil. Objetivos: El objetivo del presente trabajo es conocer la relación existente entre el rendimiento académico y el rendimiento deportivo de triatletas de entre 14 y 18 años con un alto nivel de condición física aeróbica y de entrenamiento. Métodos: Para ello se estudió el rendimiento académico y deportivo de una muestra de 14 triatletas con un alto nivel de entrenamiento y de condición aeróbica. Resultados y discusión: Los resultados muestran que existe relación entre el rendimiento académico y el rendimiento deportivo de niños triatletas de entre 14 y 18 años con un alto nivel de condición física aeróbica y de entrenamiento. Además, existe una fuerte asociación entre el rendimiento académico lingüístico y el rendimiento deportivo. Conclusiones: Existe relación entre el rendimiento académico y el rendimiento deportivo de niños triatletas de entre 14 y 18 años con un alto nivel de condición física aeróbica y de entrenamiento. Existe una fuerte asociación entre el rendimiento académico lingüístico y el rendimiento deportivo de niños triatletas de entre 14 y 18 años con un alto nivel de condición física aeróbica y de entrenamiento.Abstract: Introduction: The relationship between the level of physical condition and academic performance has been studied for decades and this association has been corroborated in the general population of children. Aim: The aim of this work is to know the relationship between academic performance and athletic performance of triathletes aged 14-18 years old with a high level of aerobic fitness and training. Methods: To this end, the academic and sports performance of a sample of 14 triathletes with a high level of training and aerobic condition was studied. Results & discussion: The results show that there is a relationship between academic performance and athletic performance of triathlete children between 14 and 18 years of age with a high level of aerobic fitness and training. In addition, there is a strong association between linguistic academic performance and athletic performance. Conclusions: There is a relationship between academic performance and athletic performance of triathlete children between 14 and 18 years old with a high level of aerobic fitness and training. There is a strong association between linguistic academic performance and athletic performance of triathlete children between 14 and 18 years old with a high level of aerobic fitness and training.Resumo: Introdução: A relação entre o nível de condição física e de rendimento académico foi objeto de estudo durante algumas décadas sendo corroborado esta associação na população geral infantil. Objetivos: O objetivo do presente trabalho é conhecer a relação existente entre o rendimento académico e o rendimento desportivo de tritatletas de entre 14 e 18 anos com um alto nível de condição física aeróbica e de treino. Métodos: Por isso se estudou o rendimento académico e desportivo d’uma mostra de 14 triatletas com um alto nível de treino e de condição aeróbica. Resultados e discussão: Os resultados mostram que existe relação entre o rendimento académico e o rendimento desportivo de crianças triatletas de entre 14 e 18 anos com um alto nível de condição física e de treino. Além d’isso, existe uma grande associação entre o rendimento académico linguístico e o rendimento desportivo. Conclusões: Existe relação entre o rendimento académico y el rendimento desportivo de crianças triatletas de entre 14 e 18 anos com um alto nível de condição física aeróbica e de treino. Existe uma grande associação entre o rendimento académico linguístico e o rendimento desportivo de crianças triatletas de entre 14 e 18 anos com um alto nível de condição física aeróbica e de treino

Differences between adjusted vs. non- adjusted loads in velocity-based training: consequences for strength training control and programming

Strength and conditioning specialists commonly deal with the quantification and selection the setting of protocols regarding resistance training intensities. Although the one repetition maximum (1RM) method has been widely used to prescribe exercise intensity, the velocity-based training (VBT) method may enable a more optimal tool for better monitoring and planning of resistance training (RT) programs. The aim of this study was to compare the effects of two RT programs only differing in the training load prescription strategy (adjusting or not daily via VBT) with loads from 50 to 80% 1RM on 1RM, countermovement (CMJ) and sprint. Twenty-four male students with previous experience in RT were randomly assigned to two groups: adjusted loads (AL) (nD13) and non-adjusted loads (NAL) (nD11) and carried out an 8-week (16 sessions) RT program. The performance assessment pre- and post-training program included estimated 1RM and full load-velocity profile in the squat exercise; countermovement jump (CMJ); and 20-m sprint (T20). Relative intensity (RI) and mean propulsive velocity attained during each training session (Vsession) was monitored. Subjects in the NAL group trained at a significantly faster Vsession than those in AL (p < 0.001) (0.88 - 0.91 vs. 0.67- 0.68 m/s, with a 15% RM gap between groups for the last sessions), and did not achieve the maximum programmed intensity (80% RM). Significant differences were detected in sessions 3- 4, showing differences between programmed and performed Vsession and lower RI and velocity loss (VL) for the NAL compared to the AL group (p < 0.05). Although both groups improved 1RM, CMJ and T20, NAL experienced greater and significant changes than AL (28.90 vs.12.70%, 16.10 vs. 7.90% and -1.99 vs. - 0.95%, respectively). Load adjustment based on movement velocity is a useful way to control for highly individualised responses to training and improve the implementation of RT programs

Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis associated cancer

The glucocorticoid receptor NR3C1 is expressed in multiple cell types in the gut and elsewhere. Intestinal epithelial cells both produce and respond to glucocorticoids in different physiological and pathological contexts. In experimental colitis glucocorticoids have been shown to exert a dual role, dampening inflammation while producing a deterioration in animal status, including death. Mice with tamoxifen inducible, intestinal epithelial specific deletion of NR3C1 (NR3C1IEC mice) are protected against experimental colitis, suggesting glucocorticoid epithelial actions are deleterious. Since glucocorticoids modulate epithelial proliferation it follows that they may affect the development of colon cancer. In this study we set out to test this hypothesis using the dextran sulfate sodium - azoxymethane model of colitis-associated cancer. KO mice were found to exhibit a 2-fold higher tumor load but similar incidence and tumor size. Tumors had a higher trend to extend to the submucosal layer (36% vs. 0%) in NR3C1IEC mice, and overexpressed Lgr5, Egfr and Myc, consistent with increased proliferation and neoplastic transformation. Snai1 and Snai2 were upregulated specifically in tumors of NR3C1ΔIEC mice, suggesting enhanced epithelial to mesenchymal transition in the absence of the intestinal epithelial GC receptor. We conclude that endogenous GC epithelial signaling is involved in colitis associated cancer.This work was supported by funds from the Ministry of Economy and Competitivity, partly with Fondo Europeo de Desarrollo Regional (FEDER) funds [SAF2017-88457-R, AGL2017-85270-R, BFU2014-57736-P, AGL2014-58883-R] and by Junta de Andalucía [CTS235, CTS164]. MA and CJA were supported by the University of Granada (Contrato Puente Program - Plan Propio) and the Ministry of Education [Spain], respectively. CIBERehd is funded by Instituto de Salud Carlos III

Role of Na+ transporters HKT1;1 and HKT1;2 in tomato salt tolerance. I. Function loss of cheesmaniae alleles in roots and aerial parts

We wish to thank Elena Sanchez Romero (EEZ-CSIC) for her technical assistance, the Scientific Instrumentation Service at EEZ-CSIC, Granada, for their ICP-OES mineral analysis and Michael O'Shea for proofreading the manuscript. The study was funded by grant AGL201782452-C2-1R (A.B.) and grant AGL2017-82452-C2-2R (M.J.A.), both from the Spanish Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion, MCIN/AEI/10.13039/501100011033, and FEDER "Una manera de hacer Europa", as well as grant ACCESP2018 (J.A.T.) from the University of Granada. J.E. was supported by a JAE Intro-CSIC grant, JAEINT_19_00566.We analyzed the physiological impact of function loss on cheesmaniae alleles at the HKT1;1 and HKT1;2 loci in the roots and aerial parts of tomato plants in order to determine the relative contributions of each locus in the different tissues to plant Na+/K+ homeostasis and subsequently to tomato salt tolerance. We generated different reciprocal rootstock/scion combinations with non-silenced, single RNAi-silenced lines for ScHKT1;1 and ScHKT1;2, as well as a silenced line at both loci from a near isogenic line (NIL14), homozygous for the Solanum cheesmaniae haplotype containing both HKT1 loci and subjected to salinity under natural greenhouse conditions. Our results show that salt treatment reduced vegetative growth and altered the Na+/K+ ratio in leaves and flowers; negatively affecting fruit production, particularly in graft combinations containing single silenced ScHKT1;2- and double silenced ScHKT1;1/ScHKT1;2 lines when used as scion. We concluded that the removal of Na+ from the xylem by ScHKT1;2 in the aerial part of the plant can have an even greater impact than that on Na+ homeostasis at the root level under saline conditions. Also, ScHKT1;1 function loss in rootstock greatly reduced the Na+/K+ ratio in leaf and flower tissues, minimized yield loss under salinity. Our results suggest that, in addition to xylem Na+ unloading, ScHKT1;2 could also be involved in Na+ uploading into the phloem, thus promoting Na+ recirculation from aerial parts to the roots. This recirculation of Na+ to the roots through the phloem could be further favoured by ScHKT1;1 silencing at these roots.Spanish Ministerio de Ciencia e Innovacion/Agencia Estatal de Investigacion AGL2017-82452-C2-1R AGL2017-82452-C2-2RFEDER "Una manera de hacer Europa" MCIN/AEI/10.13039/501100011033University of Granada ACCESP2018JAE Intro-CSIC grant JAEINT_19_0056

Epithelial deletion of the glucocorticoid receptor protects the mouse intestine against experimental inflammation

Intestinal epithelium glucocorticoid receptor knockout mice (NR3C1 IEC) were treated with dextran sulfate sodium (DSS, 2.5%) to induce colitis. Inflammatory status was assessed by morphological and biochemical methods and corticoid production was measured in colonic explants. Key Results. After 7 days of DSS NR3C1 mice exhibited lower weight loss and tissue damage, reduced colonic expression of S100A9, attenuated phosphorylation of STAT3 and a better overall state compared with WT. Ki67 immunoreactivity was also shifted, indicating an effect on epithelial proliferation. A subgroup of mice were treated with budesonide and showed completely prevented budesonide induced weight loss. Epithelial deletion of the glucocorticoid receptor also protected mice in a protracted colitis protocol. Conversely knockout mice presented a worse status compared to the control group at 1 day post DSS, as shown by blood in feces and increased inflammatory parameters. In a separate experiment colonic corticosterone production was shown to be significantly increased in knockout mice at 7 days of colitis but not at earlier stages. Conclusions and Implications. The intestinal epithelial glucocorticoid receptor has deleterious effects in experimental colitis induced by dextran sodium sulfate, probably related to inhibition of epithelial proliferative responses leading to impaired wound healing and reduced endogenous corticosterone production.Ministry of Economy and Competitivity, partly with Fondo Europeo de Desarrollo Regional FEDER funds [BFU2014-57736-P, AGL2014-58883-R, SAF2017-88457-R, AGL2017-85270-R]Junta de Andalucía [CTS235, CTS164]Ministry of EducationCIBERehd is funded by Instituto de Salud Carlos II

Uso de las TIC en la educación. Revisión de la literatura

The article presents a literature review on the use of ICT in education. Research lines were found such as: computer and digital environment; learning and education; digital competences; COVID19 and education. The analysis of these lines was carried out to guide new works on the use of ICT in education in these times of pandemic; with the aim of contributing to the improvement of teaching and learning processes.El artículo presenta la revisión bibliográfica sobre el uso de las TIC en la educación. Se hallaron líneas de investigación tales como: computador y entorno digital; aprendizaje y educación; competencias digitales; COVID19 y educación. Se realizó el análisis de estas líneas para orientar nuevos trabajos sobre la utilización de las TIC en el ámbito educativo en estos tiempos de pandemia; con el objetivo de contribuir a la mejora de procesos de enseñanza aprendizaje.O artigo apresenta a revisão bibliográfica sobre o uso das TIC na educação. Foram encontradas linhas de pesquisa como: informática e ambiente digital; aprendizagem e educação; habilidades digitais; COVID19 e educação. A análise dessas linhas foi realizada para orientar novos trabalhos sobre o uso das TIC na educação em tempos de pandemia; com o objetivo de contribuir para a melhoria dos processos de ensinoaprendizagem